Monday, December 28, 2015

Finding Appropriate or Personalised Chemotherapy (OncoFinder)

Pathway Pharmaceuticals Inc has a unique sell out used by physicians to help > 800 cancer patients in Asian and European countries for not only diagnosis cancer severity at molecular level but also to find out the specific drugs.

For cancer patients are usually under severe time crunch

Time spent is directly proportional the therapeutic efficiency. Quick diagnosis with correct therapy, provides greater chance to attain the cancer free state. Following are some important points stated by Cancer Research UK for early diagnosis of cancer:

a) 9/10 bowel cancer survives > 5 years if diagnosed in early stage
b) >90% breast cancer females survives atleast for 5 years compared to around 15% diagnosed in more advanced stage
c) >90% ovarian cancer females survives atleast for 5 years compared to around 5% diagnosed in advanced stage
d) Around 70% of patients with lung cancer will survive for atleast a year if diagnosed at early stage compared to 14% patients diagnosed with early sage condition.   (Ref)                                                                                           

Most of the time late diagnosis is attributed to a) delay in going to doctor or b) delay in diagnosis of disease and cancer type. Moreover, a recent study published showed that the condition worsens  for prostate cancer if wrong chemotherapy is given. This may also be possible for other cancer types as well. Suboptimal therapy may also lead to wastage of time to treat cancer efficiently. This may also increase the chance of recurrence of cancer or development drug resistance.                                                                                                                         

Quick identification of correct anticancer drug is need of an hour

In the previously published recommended diagnostic tests for most common cancer types; I had discussed about the most commonly used commercial methods in hospitals. Timely use of these methods helps in early diagnosis of cancer. But incorrect therapy can prove to be a spoiler. 

Oncofinder helps in determination of potential chemotherapy based on cancer type

Oncofinder is a computer aided, chemotherapy identification tool that is used by around four companies in United States, Asia and Europe as shown in figure below. Video provided shows the way by which Oncofinder works.

So basically with he help of Oncofinder computer does analyses of gene expression data from patient's tissue sample and provides best possible choices of drugs that can work on the patient's cancer condition. The method is validated on 240 patients and it works significantly. 

Patients interested to use Oncofinder identification of best possible anti-cancer drug can be accessed from here or via Pathway Pharmaceuticals. Oncofinder report generated for anti-cancer drugs can be seen here.  Oncofinder provides a unique personalised method for identification of anti-cancer drug suitable for patients based on their genetic make up or expression profiles. 

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Signal Transduction Pathways

Signal Transduction Pathways
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