Monday, April 5, 2010

The NIH underfunding the fundamental cancer biomarker research

After querying the NIH grant databases with "oncology and biomarkers" search terms (abstracts where both terms are present) for 2008, 2009 and 2010 and then filtering out grants into clinical research, infrastructure investments and behavioral & social sciences, we got surprising results:

FY Total Cost      Project Title   Principal Investigator    Organization Year NIH Institute
$1,968,645 PROSTATE CANCER IMAGING CHOYKE, PETER L NATIONAL CANCER INSTITUTE 2009 NCI
$1,686,909 MOLECULAR PROFILING OF CLINICAL SPECIMENS EDELMAN, DANIEL NATIONAL CANCER INSTITUTE 2009 NCI
$1,476,952 HUMAN RECQ HELICASES IN BIOLOGY AND ONCOLOGY MONNAT, RAYMOND J UNIVERSITY OF WASHINGTON 2009 NCI
$1,309,745 NANOTECHNOLOGY LINKING BIOMARKERS WITH CANCER
BEHAVIOR
NIE, SHUMING EMORY UNIVERSITY 2008 NCI
$787,458 ANGIOGENESIS IMAGING CHOYKE, PETER L NATIONAL CANCER INSTITUTE 2009 NCI
$657,451 A PROTEOMICS PLATFORM FOR QUANTITATIVE, ULTRA-HIGH
THROUGHPUT, AND ULTRA-SENSITIV
SMITH, RICHARD D BATTELLE PACIFIC NORTHWEST LABORATORIES 2010 NCI
$581,526 EPITOMIC BIOMARKERS OF PROSTATE CANCER CHINNAIYAN, ARUL M UNIVERSITY OF MICHIGAN AT ANN ARBOR 2008 NCI
$524,925 "MOLECULAR SIGNATURES OF LETHAL AND INDOLENT
PROSTATE CANCER"
RUBIN, MARK A. WEILL MEDICAL COLLEGE OF CORNELL UNIV 2010 NCI
$476,035 DEVELOPMENT OF IMAGING BIOMARKERS FOR TREATMENT
RESPONSE
ROSS, BRIAN D. UNIVERSITY OF MICHIGAN AT ANN ARBOR 2009 NCI
$449,756 EPITOMIC BIOMARKERS OF PROSTATE CANCER CHINNAIYAN, ARUL M UNIVERSITY OF MICHIGAN AT ANN ARBOR 2009 NCI
$397,168 A PROTEOMICS PLATFORM FOR QUANTITATIVE, ULTRA-HIGH
THROUGHPUT, AND ULTRA-SENSITIV
SMITH, RICHARD D BATTELLE PACIFIC NORTHWEST LABORATORIES 2009 NCI
$377,561 NOVEL BIOMARKERS IN OVARIAN CANCER BIRRER, MICHAEL MASSACHUSETTS GENERAL HOSPITAL 2010 NCI
$320,588 PROTEOMIC BIOMARKERS OF ALK+ LYMPHOMA LIM, MEGAN S UNIVERSITY OF MICHIGAN AT ANN ARBOR 2010 NCI
$319,550 PROGNOSTIC MARKERS FOR OVARIAN CANCER MOK, SAMUEL C UNIVERSITY OF TEXAS MD ANDERSON CAN CTR 2010 NCI
$311,250 HDGF: A NOVEL BIOMARKER AND THERAPETIC TARGET OF
LUNG CANCER
MAO, LI UNIVERSITY OF MARYLAND BALTIMORE 2009 NCI
$305,000 A TOOL FOR ANALYSIS OF GENE-SPECIFIC DNA METHYLATION
IN CLINICAL SAMPLES
LEVENSON, VICTOR V NORTHWESTERN UNIVERSITY 2009 NCRR
$283,708 CAP METASTASIS BIOMARKERS:
VALIDATION/GENOMICS/BIOLOGY
PARIS, PAMELA L UNIVERSITY OF CALIFORNIA SAN FRANCISCO 2009 NCI
$259,674 GLYCAN MARKERS FOR THE EARLY DETECTION OF BREAST
CANCER
HANCOCK, WILLIAM S NORTHEASTERN UNIVERSITY 2009 NCI
$258,053 DISCOVERY OF BIOMARKERS FOR LUNG CANCER METASTASIS PATZ, EDWARD F DUKE UNIVERSITY 2008 NCI
$248,413 NOVEL HYPERPOLARIZED C-13 AND N-15 BIOMARKERS FOR
METABOLIC MR IMAGING OF CANCER
CHEKMENEV, EDUARD VANDERBILT UNIVERSITY 2009 NCI
$223,194 INTEDRATED IMAGAING AND TISSUE BIOMARKERS IN
GLIOBLASTOMA MULTIFORME POST THERAPY
CHANG, SUSAN M UNIVERSITY OF CALIFORNIA SAN FRANCISCO 2009 NCI
$178,380 BIOMARKER MODELS OF PROSTATE CANCER OUTCOME AFTER
RADIOTHERAPY
POLLACK, ALAN UNIVERSITY OF MIAMI SCHOOL OF MEDICINE 2009 NCI
$174,701 PPARGAMMA: BIOMARKER FOR BREAST CANCER IN OLDER
WOMEN
SEO, PEARL H UNIVERSITY OF MIAMI SCHOOL OF MEDICINE 2009 NIA
$128,711 ACUPUNCTURE FOR DYSPHAGIA AFTER CHEMORADIATION FOR
HEAD AND NECK CANCER
LU, WEIDONG HARVARD UNIVERSITY (MEDICAL SCHOOL) 2009 NCCAM
$127,656 MOLECULAR PROFILES OF COLORECTAL ADENOMAS BY ARRAY
CGH
HOSTETTER, GALEN H TRANSLATIONAL GENOMICS RESEARCH INST 2009 NCI

There are only 25 meaningful projects in 2008, 2009 and 2010 with over $120,000! And that is considering hundreds of millions spent on minority research, billions spent on social and behavioral sciences... The NIH should definitely clean house sometime soon...

1 comment:

DNAmite said...

It was amazing to see Victor Levinson's epigenetic biomarker project on the list. We saw many good publications stemming from this research.

Signal Transduction Pathways

Signal Transduction Pathways
RTK, GPCR, GF, Cytokine, Wnt, Death Factors & Shh pathways