In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state
One more brilliant paper from Insilico Inc. for increasing life expectancy. A recent paper showed longevity effect of following 10 compounds (table 1). May be some day we will be able to live longer life. For details click on the above mentioned link. Paper if available free online.
Table 1. Letter codes for the test conditions.
Cells | Substance | Code |
young | - | Y |
old | - | O |
old | Nordihydroguaiaretic acid (NDGA) | A |
old | Myricetin | B |
old | HA-1004 | C |
old | 7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | D |
old | Staurosporine | E |
old | Ursolic acid | F |
old | N-acetyl-L-cysteine (NAC) | G |
old | Fasudil (HA-1077) | H |
old | PD-98059 | I |
old | Epigallocatechin gallate (EGCG) | J |
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