Sunday, January 15, 2017

Top 10 molecules predicted to fight aging

In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state


One  more brilliant paper from Insilico Inc. for increasing life expectancy. A recent paper showed longevity effect of following 10 compounds (table 1). May be some day we will be able to live longer life. For details click on the above mentioned link. Paper if available free online.



Table 1. Letter codes for the test conditions.

CellsSubstanceCode
young-Y
old-O
oldNordihydroguaiaretic acid (NDGA)A
oldMyricetinB
oldHA-1004C
old7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamineD
oldStaurosporineE
oldUrsolic acidF
oldN-acetyl-L-cysteine (NAC)G
oldFasudil (HA-1077)H
oldPD-98059I
oldEpigallocatechin gallate (EGCG)J

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Signal Transduction Pathways

Signal Transduction Pathways
RTK, GPCR, GF, Cytokine, Wnt, Death Factors & Shh pathways